In addition, several studies have shown that stathmin is a potential therapeutic target because a stathmin-transfected lung cancer cell line has increased sensitivity to Vinca alkaloids (Nishio et al, 2001), and antisense inhibition of stathmin expression showed a synergistic apoptotic effect in combination with paclitaxel treatment (Iancu et al, 2000). This evidence concerns the gene STMN1 and lung cancer.