Given the relevance of E-cadherin in tumour development and progression and the different mechanisms involved in its regulation, we set out to use a genome-wide expression analysis to identify genes or pathways in mammary epithelial cells that are either (in)directly affected by loss of E-cadherin function or are altogether associated with a (epi)genetic programme that determines the biological status of cells: epithelial or mesenchymal. The gene discussed is CDH1; the disease is neoplasm.