EGFR and head and neck cancer: Epidermal growth factor receptor is also implicated in angiogenesis, ability to metastasise, and inhibition of apoptosis (Baselga, 2000; Shintani et al, 2003a, 2003b) Indeed, EGFR expression has been found to relate closely to prognosis in head and neck cancer, higher levels correlating with poorer progression-free and overall survival (Nicholson et al, 2001).