The overexpression of the CCND1 gene occurs in more than one-third of all colorectal cancers (Arber et al, 1996) and adenoma (Weinstein et al, 1997), and expression of an antisense CCND1 cDNA suppresses the growth of colon cancer cells in animal models (Arber et al, 1997). The gene discussed is CCND1; the disease is adenoma.