The strongest evidence, to date, has linked the CCND1 A870G polymorphism with an increased risk of colorectal cancer and adenoma in many (Kong et al, 2000, 2001; Bala and Peltomaki, 2001; Porter et al, 2002) though not all studies (McKay et al, 2000). The gene discussed is CCND1; the disease is colorectal cancer.