Moreover, the CCND1 A870G genotype (Kong et al, 2000) or the presence of the variant truncated CCND1 transcript (preferentially encoded by the A870G genotype) (Bala and Peltomaki, 2001) was associated with a younger age of cancer onset in subjects with hereditary nonpolyposis colorectal cancer (HNPCC). This evidence concerns the gene CCND1 and cancer.