Previous studies reported a younger age of onset for colorectal cancer for subjects with HNPCC who possessed the AA or GA CCND1 genotype or the presence of the variant truncated CCND1 transcript (preferentially encoded by the A870G genotype) (Kong et al, 2000; Bala and Peltomaki, 2001). This evidence concerns the gene CCND1 and hereditary nonpolyposis colon cancer.