Previous studies reported a younger age of onset for colorectal cancer for subjects with HNPCC who possessed the AA or GA CCND1 genotype or the presence of the variant truncated CCND1 transcript (preferentially encoded by the A870G genotype) (Kong et al, 2000; Bala and Peltomaki, 2001). The gene discussed is CCND1; the disease is colorectal cancer.