Furthermore, the ability of antiproliferative agents to inhibit the expression of these proteins is important, since cyclins A, B1, E, and D1 have been correlated with prostate cancer aggressiveness (Mukhopadhyay et al, 2002; Maddison et al, 2004; Tsao et al, 2004). Here, CCNA2 is linked to Familial prostate cancer.