Previous studies suggested that disruption of the activity of the photoreceptor-specific transcriptional activator Crx may play a role in SCA7 retinopathy by its direct interaction with ATXN7 and that TFTC/STAGA complexes might act as coactivators for Crx-mediated transcriptional activity [20,40,41]. The gene discussed is CRX; the disease is spinocerebellar ataxia 7.