When combined with other environmental factors, logistic regression analysis identified H. pylori infection (O.R. 2.41; 95% CI 1.20–4.84), and alcohol intake (O.R. 7.09; 95% CI 2.23–22.51) but not or CagA + serology as independent factors associated with Barrett's esophagus. Here, S100A8 is linked to Barrett esophagus.