TCF1 and TCF2, respectively, encode the transcription factors hepatocyte nuclear factor 1α and β (HNF1α and HNF1β), two POU-homeodomain proteins that bind to an essential element in the proximal promoter sequences of albumin and many other tissue-specific genes and are associated with development, metabolism and cancer (Cereghini et al, 1987; Courtois et al, 1987; Frain et al, 1989; Rey-Campos et al, 1991). This evidence concerns the gene HNF1A and cancer.