APC and ovarian serous adenocarcinoma: It has been suggested that downregulated expression of APC (Karbova et al, 2002) or secreted frizzled-related proteins (SFRPs) inactivation by methylation (Takada et al, 2004) could explain, at least partially, why ovarian serous adenocarcinomas show increased β-catenin protein expression in spite of the absence of gene mutation.