Although Ets-1 DNA binding activity is increased in scleroderma fibroblasts [15], the Ets family member Fli-1 has reduced expression in this cell type [16]; however, the consequences of altering the Ets-1/Fli-1 ratios on mesenchymal biology has yet to be fully appreciated. The gene discussed is FLI1; the disease is scleroderma.