Given that Ets-1 is induced during the early phases of tissue repair [14,38,39] and is overexpressed in tumor stroma, [12,13,41], these results, although albeit using principally promoter-based approaches, collectively suggest that Ets-1 could bias the fibroblast population towards a 'pro-migratory' program in that TGFβ and Ets-1 interactions may bias Ets-1 and TGFβ-responsive genes toward a migratory/adhesive/invasive phenotype. This evidence concerns the gene ETS1 and neoplasm.