Nine (8.8%) of the RA patients from the present study exhibited five of these new PADI4 variants – 265G→A (D89T) (n = 2), 390194C→T (n = 1), 304C→A (P102T) (n = 1), 393030A→G (n = 1), and 392G→C (R131T) (n = 3) – and another previously unknown PADI4 variant – 236C→G (T79R), EMBL AJ966355 (n = 1). Here, PADI4 is linked to rheumatoid arthritis.