Nakahara et al (1997) observed the preferential localisation and functional significance of MT1-MMP in the invadopodia of melanoma cells. Localisation studies suggest that stromally derived MT1-MMP may be cleaved from the cell surface and that the resulting soluble protein is endocytosed and re-expressed by the tumour cells (Chenard et al, 1999), but this is currently unsubstantiated. Here, MMP14 is linked to neoplasm.