NES and malignant glioma: Using immunohistochemical staining of paraffin-embedded tissue sections, nestin expression has been detected in brain tumors and tumors derived from CNS tissues, such as, neurocytomas, gangliogliomas, ependymomas, pilocytic astrocytomas, malignant gliomas including glioblastoma multiforme, primitive neuroectodermal tumors (PNETs), medulloblastomas and medulloepitheliomas [4,11-16].