Comparing histological parameters with each other, tumor size correlated significantly with lymph node involvement (p < 0.001), grading (p < 0.001) and lymphangiosis (p < 0.001), and lymph node metastasis correlated with grading (p = 0.001), estrogen receptor negativity (p < 0.001), and lymph- and hemangiosis (p < .001 each). The gene discussed is ESR1; the disease is neoplasm.