To investigate if these biological factors could predict the presence of DTC-BM, and which of them are correlated with survival data, we examined the expression and amplification of HER2, Top IIa, Ki 67, and p53 on tissue micro arrays (TMAs) of 265 breast cancer patients with known bone marrow (BM) status at the time of primary diagnosis. This evidence concerns the gene ERBB2 and breast carcinoma.