TP53 and breast cancer: Our data indicate that DHEA and DHEA 8354 at doses of 1,000 mg/kg diet had the following effects: they decreased the multiplicity and the weight (burden) of mammary tumors; they induced cellular senescence; they inhibited cell proliferation; they arrested the cells in G1/G0 phases of the cell cycle; they increased apoptotic cell death; and they induced the expression of p16 and p21 but not that of p53.