Recently, we have shown that FADD phosphorylation at Ser194 can be induced by paclitaxel, with impact on functions both upstream and downstream of the MEKK1/MKK7/JNK1 pathway, closely associated with sensitisation to chemotherapy in prostate cancer cells (Shimada et al, 2002, 2004). The gene discussed is MAPK8; the disease is prostate cancer.