MAPK8 and breast carcinoma: The same mechanisms appeared also to be operating in ER-positive MCF-7 breast cancer cells: paclitaxel at the same concentration caused JNK activation/FADD phosphorylation, and cell cycle arrest at G2/M, which were cancelled by the JNK inhibitor or S194A mutant FADD overexpression (Figure 3A, right panels) (Figure 3B, lower panels) (Figure 3C, right bars) (Figure 3D black bars).