Other investigations showed that the amplification of the PI3K locus as well as deletions of short nucleotide sequences resulted in elevated lipid kinase activity of the p110α catalytic subunit of PI3K (PIK3CA) in various cancer types with the implication that PI3K was functioning as an oncogene (Volinia et al, 1994; Shayesteh et al, 1999; Ma et al, 2000; Katso et al, 2001; Migozuchi et al, 2004; Pedrero et al, 2005). The gene discussed is PIK3CG; the disease is cancer.