We also investigated the promoters of the cyclin A1 (CYCA1) gene, which has recently been suggested as a promising candidate gene for epigenetic silencing in HNSCC (Tokumaru et al, 2004), and the cytoblogin (CYGB) gene, which has been implicated in oesophageal and lung cancer within our own group (unpublished), but not previously investigated in OSCC. This evidence concerns the gene CYGB and lung carcinoma.