Metabolic control is normally obtained with diet, physical exercises and/or concomitant use of oral hypoglycemic agents, and insulin may be used for treatment; 3) secondary diabetes - type of diabetes in which the causal factor is known, such as some genetic defects that result in abnormalities of beta cell function or insulin action, some pancreatic and endocrine diseases, or those caused by some drugs; 4) gestational diabetes - it is primarily diagnosed during pregnancy and it may disappear at the end of the pregnancy period. The gene discussed is INS; the disease is endocrine system disorder.