FN1 and neoplasm: Its expression has been related to poor prognosis of head and neck tumors, a fact confirmed by the studies developed by Kannan et al.18in the normal oral mucosa and squamous cell carcinomas, and by Zidar et al.30who detected gradual increase of fibronectin on basal membranes of laryngeal squamous cell carcinomas, detecting also expression which was inversely proportional to density of associated inflammatory infiltrate and level of tumor differentiation.