Intracytoplasmatic immunomarking of fibronectin was observed in 16.7% of tongue squamous cell carcinomas, contrarily to the lips, in Miranda31 study, which may, according to the author, be indicative that tumor cells and not only stromal cells may synthesize fibronectin, building up on the basal membrane and peritumor matrix to probably facilitate adherence and posterior migration through tumor stroma. This evidence concerns the gene FN1 and neoplasm.