Upon analyzing 25 non-metastatic oral squamous cell carcinoma and 19 metastatic carcinomas using immunohistochemical and zymography techniques, Hong et al.1compared expression and activity of MMPs-2 e –9 in these groups and detected that MMP-9 would play an even bigger role in the development of metastases than MMP-2. The gene discussed is MMP2; the disease is oral cavity squamous cell carcinoma.