Miranda31 analyzed the correlation of expression pattern of many proteins in ECM, such as laminin, collagen I and IV, fibronectin and tenascin in lower lip and tongue squamous cell carcinoma with varied histology grading, and observed that collagen IV and laminin were absent on the basal membrane of neoplastic cell nests of most studied cases and when present, marking was weak. The gene discussed is LAMB2; the disease is tongue squamous cell carcinoma.