The proportion of patients who are more HRH-intensive due to clinical factors will depend on the population targeted, the stage of the HIV/AIDS epidemic in the community, access to both HIV testing and care (better access may lead more asymptomatic individuals to learn their status and present for care at an earlier stage), availability of ART at other sites in the area, and availability of CD4 counts to identify individuals with advanced immunosuppression before they develop complications. The gene discussed is CD4; the disease is AIDS.