Within 2–3 wk after doxycycline removal, Smad7 expression inPdx1-tTA/Smad7 islets was detected (Figure 2H–J), and bitransgenic mice (Figure 3) developed significant hyperglycemia during random feeding (Figure 3A) and showed impaired glucose tolerance (Figure 3B). The gene discussed is SMAD7; the disease is Hyperglycemia.