BRCA1 and Familial prostate cancer: Although there was some variability from cell line to cell line, these studies show reproducible induction of BRCA1 and BRCA2 by I3C, with increases in BRCA1 and BRCA2 protein levels at an I3C dose of 60 μM at 24 h of (5–10)-fold for the breast cancer cell lines and (8–16)-fold for the prostate cancer cell lines.