AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Akt is frequently activated in various cancers and moreover, high levels of phosphorylated (activated) Akt is a poor prognostic indicator in CML (Vivanco and Sawyers, 2002; Xu et al, 2003; Thompson and Thompson, 2004; Grandage et al, 2005).