It has been reported that AT1R is expressed in various human malignant tumour tissues, including breast cancer (Inwang et al, 1997), skin cancer (Takeda and Kondo, 2001), pancreatic cancer (Fujimoto et al, 2001), laryngeal carcinoma (Marsigliante et al, 1996) and prostate cancer (Uemura et al, 2003). This evidence concerns the gene AGTR1 and cancer.