Indeed, the present assessment of the oxidative stress hypothesis in blood and tumour tissue is the first to establish a biological rationale – in humans – for the use of histamine in conjunction with IL-2 despite several clinical trials (Brune and Hellstrand, 1996; Mellqvist et al, 1999; Agarwala et al, 2002, 2004; Lurie et al, 2002; Schmidt et al, 2002; Donskov et al, 2002b). The gene discussed is IL2; the disease is neoplasm.