In support of this notion, EGF, EGFR, TrkA/NGF receptor and the ligand NGF have been shown to bind to chromatins (Rakowicz-Szulczynska et al, 1988; Kamio et al, 1990) and Schwannoma-derived growth factor, a ligand for EGFR, bound to A+T-rich DNA sequences (Kimura, 1993). The gene discussed is EGFR; the disease is schwannoma.