Interestingly, when we used disease-association highlight feature in WPS (see Additional file 6 for screenshot), we found that Rab4a , Ldlr , and srebf1 are all more or less associated with obesity annotated in Genetic Association Database [33] and MedGene databases [34] (data not shown). The gene discussed is LDLR; the disease is obesity due to melanocortin 4 receptor deficiency.