Of these, 25 have a mutation frequency above 5% in one or more tumour type while the other three, ERBB2, FGFR2 and SUFU, have biologically plausible mutations but a low mutation frequency (mutation frequencies in all available data are; 1.2% for ERBB2, 2% for FGFR2 and 1.6% for SUFU). The gene discussed is ERBB2; the disease is neoplasm.