BIRC5 and ductal breast carcinoma in situ: When the 5-year cumulative disease free survival was plotted against cytoplasmic survivin status as Kaplan–Meier graphs, DCIS that was cytoplasmic survivin positive (scores of 2 and 3+) had a significantly poorer 5-year outcome than cytoplasmic survivin negative cases (scores of 0 and 1+) (Figure 2A and B).