Most of those scoring systems are based on easily available clinical and laboratory parameters such as differences in age distribution, period between onset of disease and admission, absence of meningitis, presence of widespread skin lesions, hypotension, metabolic acidosis, normal C-reactive protein level, absence of leukocytosis, presence of thrombocytopenia, and hypofibrinogenemia [22-25]. This evidence concerns the gene CRP and Hypofibrinogenemia.