In addition, the model has withstood the test of time in the sense that it remains consistent with newer discoveries such as the escalating risk for developing breast cancer associated with HELUs (about twofold), ADH (about fivefold), and DCIS (about 10-fold) [5,6,24-29], and the shared genetic alterations between them, especially when they occur in the same breasts [30-34]. This evidence concerns the gene AVP and ductal breast carcinoma in situ.