The familial relative risks predicted by this model are closer to the observed risks than those predicted by the previous version (Antoniou and coworkers, unpublished data). BRCA2 mutations (and, to a lesser extent, BRCA1 mutations) are associated with increased risks for male breast cancer, prostate cancer and pancreatic cancer, and several other cancers have been reported to occur at increased frequency in BRCA1 or BRCA2 carriers [11,46,47]. This evidence concerns the gene BRCA1 and familial pancreatic carcinoma.