COMT and breast carcinoma: Lavigne et al. [21] found an elevated risk of breast cancer for COMT-LL women compared to COMT-HH women, and this increased risk was greater for non-smokers (OR = 2.8) than smokers (OR = 1.8), suggesting that cigarette smoking attenuates any increased risk of breast cancer for women with slow catechol-O-methyltransferase activity.