Although our findings of a potential protective effect of the non-wild-type apoC-III variants on PI-induced hypertriglyceridemia in Hispanics is not consistent with studies in White samples, they are not surprising in the context of prior studies that demonstrated complex transcriptional regulation of the apoA-I/CIII/AIV/AV gene cluster [55], race/ethnic specific LD across this region [36–38], interplay of distinct alleles that confer susceptibility/resistance to hypertriglyceridemia [28,29,39,45,50], and prior evidence for modification of apoC-III effects by race/ethnicity [38,40]. Here, APOC3 is linked to hypertriglyceridemia.