ANGPT2 and Sepsis: Circulating Ang-1 was not different between cases and controls (unpublished data), but Ang-2 at the time of enrollment (Figure 1) was 23.2 ± 9.1 ng/ml among patients with severe sepsis—defined by the presence of shock or multi-organ dysfunction (third bar, n = 17)—compared with only 3.5 ± 0.6 ng/ml among non-septic hospitalized controls (first bar, n = 29, p = 0.0071) and 4.8 ± 1.5 ng/ml among patients with sepsis but who did not have shock or multi-organ dysfunction (second bar, n = 5).