Interestingly, tumors possessing a deletion or polymorphism in TSC1/TSC2 displayed a trend for higher levels of HIF-1α and a single tumor with both a HIF-1α polymorphism and an exon 36 and 40 TSC-2 deletion manifest the highest levels of HIF-1α (Figure 2 & 3). The gene discussed is TSC2; the disease is neoplasm.