Factor VII is a vitamin-K dependent clotting factor in the extrinsic pathway that – when deficient – is inherited as an autosomal recessive trait and produces an elevated partial thromboplastin time (PTT) in the face of a normal activated prothrombin time (PT); hemarthrosis; intracranial hemorrhage; hematuria; spontaneous epistaxis and bruising; and genitourinary and gastrointestinal bleeding. Here, F2 is linked to intracranial hemorrhage.