Moreover, when we compared the immunohistochemical staining pattern of SM5-1 with that of anti-MART-1 (mAb A103) and anti-tyrosinase (mAb T311) we found an overall reactivity of 92% (318/344) for SM5-1, 83% (285/344) for MART-1 and 71% (245/344) for tyrosinase in primary and metastatic melanoma specimens. Here, TYR is linked to metastatic melanoma.