Furthormore, a significant inverse correlation between Survivin cytoplasmic expression and tumour apoptosis was observed (P <0.001), that is, in the GBMs with positive expression of cytoplasmic Survivin, 84% (31 out of 37) were observed to have a low AI (AI<0.76), whereas in the GBMs showing negativity of cytoplasmic Survivin (17 out of 19, 89%), a high AI (AI⩾0.76) was found (see Table 1 and 2). This evidence concerns the gene BIRC5 and neoplasm.