Both encode transcription factors that are thought to play a role in tumorigenesis, LRCC (Leiomyomatosis and Renal Cell Cancer, 1q42-44 in human) is associated with papilloma renal cancer, while WTSL (Wilms tumor suppressor locus, 7p14-13 in human) is a potential suppressor gene whose alteration appears to be involved in normal kidney development and nephroblastoma. This evidence concerns the gene POU6F2 and hereditary leiomyomatosis and renal cell cancer.