In addition to this situation, the two other integration sites identified in the most developed tumor by BACs 15 and 2 corresponded respectively to ccn3/nov (8q24.1 in human) and AdamTS1 (21q23.1 in human), two genes whose involvement in angiogenesis, matrix remodeling and tumorigenesis is well documented [7,19-27]. The gene discussed is ADAMTS1; the disease is neoplasm.