The growing evidence of the presence of intracellular hyaluronan and its interaction with intracellular hyaladherins such as CDC37, IHABP4 [5,8] and further the subsequent loss of HA interaction with its receptor during the late malignancy led us to compare the distribution of H11B2C2 (one of the HA receptor detected from IVd4 hybridoma) receptor and hyaluronan expression in multiple cancer tissues in later invasive stages. The gene discussed is CDC37; the disease is cancer.