This last case was particularly interesting because a clonal evolution was demonstrated from a clone with a trisomy 8 to a clone with a translocation event with a chromosome 17 der(17)t(8;17)(q11.2, p13.1) resulting in a trisomy for the long arm of chromosome 8 and a monosomy for the distal region of chromosome 17 suggesting TP53 deletion is a secondary change of importance in the progression of the neoplasia. This evidence concerns the gene TP53 and neoplasm.