DES and leiomyosarcoma: Histological examination revealed all to be high-grade leiomyosarcomas composed of spindle cells with positive immunohistochemistry staining for Desmin, HHF 35(muscle specific actin), SMA (smooth muscles actin), and negative for epithelial marker AE1/AE3, S100 protein confirming smooth muscles origin, and excluding nerve sheath origin (Figure 3).