Given the ability of C/EBPbeta-2 to confer EGF-independent growth to mammary epithelial cells as well as its capability for disrupting normal epithelial architecture and causing EMT, it is worth considering whether aberrant C/EBPbeta-2 expression could contribute to the resistance of some breast cancers to targeted therapies such as Herceptin. This evidence concerns the gene EGF and breast carcinoma.