AGT and hypertensive disorder: According to a previous study carried out among Caucasian women to examine the association between the AGT T235 variant and preeclampisa (PE) (hypertension with proteinuria), the AGT T235 allele frequency was significantly higher among primiparous women with PE with respect to the control group (65% vs. 40%).12 On the other hand, in the Japanese population, the T235 variant was strongly associated with the incidence of HP, regardless of parity.