GSK3B and early-onset autosomal dominant Alzheimer disease: Therefore, functional kinase activity of GSK-3β is important in a variety of biological and biochemical processes and altered GSK-3β activity can contribute to a number of pathological processes including bipolar mood disorder [12-14], schizophrenia [15], heart disease [16,17], neurodegeneration [18] Alzheimer's disease [11,19] and diabetes mellitus [11,19,20].