Real time-PCR studies of the ENO1 gene on cDNA-samples showed a 55% reduction (p = 0.01) of ENO1-mRNA levels in stage 4 neuroblastoma tumours compared to stage 2 tumour levels (average relative concentration of 0.5 in stage 2 tumours compared to 0.23 in stage 4 tumours). Here, ENO1 is linked to neuroblastoma.