Antibodies reacting with Ro52 peptides 1–13 and 365–382 were also particularly elevated in lupus mothers of group I. In contrast, no statistically significant difference was observed between groups I and II of mothers with SS, and low levels of Ro peptide reactive antibodies were measured in asymptomatic mothers who gave birth to babies with NLE. Here, TRIM21 is linked to synovial sarcoma.