The appearance of IgG antibodies to Ro antigens (Ro52, Ro60, La proteins and the 45 peptides of Ro52 and Ro60) was then examined in serial samples from lupus mothers of groups I and II in order to establish, in a more individual manner, whether correlations exist between the presence of these antibody subsets and different parameters related to the disease, the treatment and the course of pregnancy. This evidence concerns the gene TRIM21 and systemic lupus erythematosus.