Tumor necrosis factor (TNF) induced sustained VCAM-1 expression within 4 h in the lung, liver and kidney of mice [31], and increased the adhesion of highly metastatic murine carcinoma cell line H-59, and human colorectal carcinoma lines HM 7 and CX-1 to murine hepatic endothelial cells in the primary culture. The gene discussed is TNF; the disease is carcinoma.