Blockade of VCAM-1 expression in vivo with specific antibodies, administered before B16M cell injection into the portal circulation, decreased sinusoidal retention of luciferase-transfected B16M cells by 85%, and metastasis development by 75%, indicating that VCAM-1 expression on tumor-activated sinusoidal endothelial cells had a prometastatic contribution [35]. The gene discussed is VCAM1; the disease is neoplasm.